From the Executive Summary
Exposure to microbial contaminants is clinically associated with respiratory symptoms, allergies, asthma and immunological reactions.
Toxicological evidence obtained in vivo and in vitro supports
these findings, showing the occurrence of diverse inflammatory and toxic responses after exposure to microorganisms isolated from damp buildings, including their spores, metabolites and components.
From Chapter 2:
Mycotoxins, or fungal toxins, are low-relative-molecular-mass biomolecules produced by fungi, some of which are toxic to animals and human beings. Mycotoxins are known
to interfere with RNA synthesis and may cause DNA damage.
From a report on Neurotoxic Effects
The Validity of the Environmental Neurotoxic Effects of Toxigenic Molds and Mycotoxins
"Exposure to mycotoxin may occur via enteric, inhalation, or direct contact to skin and mucosa. Acute and chronic disorders, irritation, systemic reactions, and even cancer may develop after the exposure to these toxins."
"Symptoms include respiratory complaints that involve the nose and lungs; eye symptoms, and mucous membrane irritation. The major presentations are headache, general debilitating pains, nose bleeding, fevers with body temperatures up to 40 degrees C (104 degrees F), cough, memory loss, depression, mood swings, sleep disturbances, anxiety, chronic fatigue, vertigo/dizziness, and in some cases, seizures."
"Mycotic demyelinating optic neuritis is a neurological disorder of the visual system caused by mycotoxins released by indoor toxic molds."
"Other neurobehavioral manifestations in the mold-exposed individuals are abnormal decrease in steady balance, reaction time, blink-reflex latency, color discrimination, visual fields, and grip, compared to control. Hence, most exposed patients have reduced cognitive functioning in multiple domains, with memory and executive functions the most commonly affected areas."
From a Wire Service Canada article (January 27, 2010)
B.C. Company Fights Back Against Sick Building Syndrome
"William Fisk from Lawrence Berkeley National Laboratory in California established a baseline for quantifying benefits from improved IAQ and demonstrated the economic impacts of increased productivity. Findings are showing that improvement in IAQ can: Reduce SBS symptoms by 20 to 50 percent, with estimated savings of $10 to $100 billion; Reduce asthma by 8 to 25 percent, with estimated savings of $1 to $4 billion; Reduce other respiratory illnesses by 23 to 76 percent, with estimated savings of $6 to $14 billion; Improve office worker productivity by 0.5 to 5 percent, with estimated savings of $20 to $200 billion."
From the ACGIH book titled "Bioaerosols: Assessment and Control"
Be sure to check out the list of symptoms on page 24-3
of this book.
To purchase the book from ACGIH, go to:
From a November 2012 Alert by NIOSH (National Institute of Occupational Safety and Health)
Preventing Occupational Respiratory Disease from Exposures Caused by Dampness in Office Buildings, Schools, and Other Nonindustrial Buildings
Occupants within damp office buildings, schools, and other nonindustrial buildings may develop respiratory symptoms and disease.
NIOSH has estimated that 29% to 33% of new-onset adult asthma is attributable to work-related exposures and 23% of existing adult asthma is exacerbated by work. If occupants develop asthma or asthma exacerbation while working in damp buildings, medical treatment may not be effective if the occupant continues to be exposed. An occupant in damp buildings with allergic asthma may experience symptoms after exposure to very low levels of a
sensitizing agent that may still be present after remediation; in such cases, an occupant may require relocation to another area.